The improvement of amorpha-4,11-diene production by a yeast-conform variant
نویسندگان
چکیده
منابع مشابه
Improvement of amorpha-4,11-diene production by a yeast-conform variant of Vitreoscilla hemoglobin.
Amorpha-4,11-diene is the precursor of the antimalarial compound artemisinin. The effect of Vitreoscilla hemoglobin (VHb) and its yeast-conform variant (VHbm) on amorpha-4,11-diene production in engineered Saccharomyces cerevisiae was investigated. First, the VHb gene was mutated to the yeast-conform variant VHbm based on step-by-step extension of a short region of the gene through a series of ...
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Dynamic control of ERG9 expression for improved amorpha-4,11-diene production in Saccharomyces cerevisiae
BACKGROUND To achieve high-level production of non-native isoprenoid products, it requires the metabolic flux to be diverted from the production of sterols to the heterologous metabolic reactions. However, there are limited tools for restricting metabolic flux towards ergosterol synthesis. In the present study, we explored dynamic control of ERG9 expression using different ergosterol-responsive...
متن کاملThe presence of amorpha-4, 11-diene synthase, a key enzyme in artemisinin production in ten Artemisia species
BACKGROUND AND THE PURPOSE OF THE STUDY Artemisinin is one of the most effective medicine against malaria, which is produced naturally by Artemisia annua in low yield. It is produced in a metabolic pathway, in which several genes and gene products are involved. One of the key genes in this pathway is am1, which encodes amorpha-4, 11-diene synthase (ADS), a key enzyme in artemisinin biosynthesis...
متن کاملHigh-Level Production of Amorpha-4,11-Diene, a Precursor of the Antimalarial Agent Artemisinin, in Escherichia coli
BACKGROUND Artemisinin derivatives are the key active ingredients in Artemisinin combination therapies (ACTs), the most effective therapies available for treatment of malaria. Because the raw material is extracted from plants with long growing seasons, artemisinin is often in short supply, and fermentation would be an attractive alternative production method to supplement the plant source. Prev...
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ژورنال
عنوان ژورنال: Journal of Applied Microbiology
سال: 2009
ISSN: 1364-5072,1365-2672
DOI: 10.1111/j.1365-2672.2008.04063.x